Dr Lucio Marcello


ResearcherLucio Marcello


+44 (0)1463 273272

My background is in molecular genetics, bioinformatics and host-parasite interactions, having worked at the University of Glasgow on several projects relating to Human African Trypanosomiasis. I have recently joined the Rivers and Lochs Institute and coordinate the AMBER working group, with a focus on biodiversity and habitat assessment of the River Ness case study, through eDNA methodology and conventional survey methods. I am also investigating archive materials, to chart the impact of dams and other land use changes over time, and reconstruct baseline biodiversity for the Ness river system.

Research Interests

  • eDNA applied to understanding freshwater ecology
  • impact of dams on rivers and biodiversity
  • population genetics and phylogeny
  • mitochondrial evolution and plasticity
  • public engagement and citizen science

Current projects

AMBER - Adaptive Management of Barriers in European Rivers

NORDCHAR - using new genetic methodologies as well as conventional life history ecology methods to make model-based analyses on the effects of climate change


Jones J, Börger L, Tummers J, Jones P, Lucas M, Kerr J, Kemp P, Bizzi S, Consuegra S, Marcello L, Vowles A, Belletti B, Verspoor E, Van de Bund W, Gough P, Garcia de Leaniz, C. A comprehensive assessment of stream fragmentation in Great Britain. Science of The Total Environment. 2019; 673:756–762.

Marques CA, Tiengwe C, Lemgruber L, Damasceno JD, Scott A, Paape D, Marcello L, McCulloch R. Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Res. 2016 Mar 6

Machado CR, Vieira-da-Rocha JP, Mendes IC, Rajão MA, Marcello L, Bitar M, Drummond MG, Grynberg P, Oliveira DA, Marques C, Van Houten B, McCulloch R. Nucleotide excision repair in Trypanosoma brucei : specialization of transcription-coupled repair due to multigenic transcription. Molecular Microbiology. 2014; 92 (4).

Tiengwe C*, Marcello L*, Farr H*, Dickens N, Kelly S, Swiderski M, Vaughan D, Gull K, Barry JD, Bell SD, McCulloch R. Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei. Cell Rep. 2012 Jul 26;2(1):185-97  (*) shared first author

Tiengwe C*, Marcello L*, Farr H*, Gadelha C, Burchmore R, Barry JD, Bell SD, McCulloch R. Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS One. 2012; 7(3)  (*) shared first author

Jackson AP, Berry A, Aslett M, Allison HC, Burton P, Vavrova-Anderson J, Brown R, Browne H, Corton N, Hauser H, Gamble J, Gilderthorp R, Marcello L, McQuillan J, Otto TD, Quail MA, Sanders MJ, van Tonder A, Ginger ML, Field MC, Barry JD, Hertz-Fowler C, Berriman M. Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3416-21

Morrison LJ, Marcello L, McCulloch R. Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity. Cell Microbiol. 2009 Dec; 11(12):1724-34. Review

Marcello L, Barry JD. Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure. Genome Res. 2007 Sep; 17(9):1344-52. Epub 2007 Jul 25.

Marcello L, Menon S, Ward P, Wilkes JM, Jones NG, Carrington M, Barry JD. VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins. BMC Bioinformatics. 2007 May 2; 8:143.

Marcello L, Barry JD. From silent genes to noisy populations-dialogue between the genotype and phenotypes of antigenic variation. J Eukaryot Microbiol. 2007 Jan-Feb; 54(1):14-7. Review.

Pays E, Salmon D, Morrison LJ, Marcello  L, Barry JD. Antigenic variation in Trypanosoma brucei. In: Barry JD, McCulloch R, Mottram J, Acosta-Serrano A, editors. Trypanosomes: after the genome, Horizon Press; 2007, Ch. 11. Book chapter.  

Barry JD, Marcello L, et al. What the genome sequence is revealing about trypanosome antigenic variation. Biochem Soc Trans. 2005 Nov; 33(Pt 5):986-9. Review.

Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Böhme U, Hannick L, Aslett MA, Shallom J, Marcello L, … Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. The genome of the African trypanosome Trypanosoma brucei. Science. 2005 Jul 15; 309(5733):416-22.

McCready S, Marcello L. Repair of UV damage in Halobacterium salinarum. Biochem Soc Trans. 2003 Jun; 31(Pt 3):694-8

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